Categories (7)

Articles (18)

Dangerous Gas Policy

The purpose of this policy is to establish minimum standards for lab researchers that utilize dangerous gases. These standards will reduce the likelihood of a dangerous gas release and ensure the safety of laboratory researchers, building occupants and emergency responders.

Instructions for Preparing a Hazard Management Program

The Hazards Management Plan (see attached document) has nine essential elements and each of these are addressed in a different section of the plan. Each section provides information to EHS on the personnel within the work unit (i.e. change in location and/or change in tasks). The following instructions provide information on how to complete each section of the plan.

Mercury-Free UNC Policy

Mercury pollution is one of the most significant environmental toxins found in the United States. The Environmental Protection Agency (EPA) and a variety of public health organizations have identified mercury elimination as one of their highest priorities in recent years.

Moisture Intrusion Events Policy

This document provides the University of North Carolina at Chapel Hill with a set of practices and procedures used during a response to a moisture intrusion event. This document also define roles and responsibilities for departments during moisture intrusion events on campus.

Nanotechnology Safety Policy

The University of North Carolina at Chapel Hill is one of the leaders in research devoted to nanotechnology. University researchers are working with and developing novel nanomaterials between 1 and 500 nanometers (nm) in size. Currently, there is limited occupational safety information on nanoparticles and nanomaterials in the university research environment.

No Smoking Policy

The University of North Carolina at Chapel Hill (the “University”) is dedicated to maintaining a healthy work and learning environment free from the potential health hazards from exposure to smoke or vapor.

Procedure for Vacating/Moving Laboratory Space

Written notification to the UNC Department of Environment, Health & Safety (EHS) is required prior to vacating a lab or moving into a different lab. Prior to moving into a new lab, the room/s must be authorized and posted for radiation use. When vacating a lab, remove all sources of radiation from the lab space, source vials, aliquots of radioactive material, experiments containing radioactive material and radiation waste.

Standard Operating Procedure for Chloroform (Methylidyne Trichloride, Trichloromethane)

Chloroform (CAS 67-66-3) is commonly used in laboratories during DNA purification procedures in biology and biochemistry and also as a solvent in organic synthesis. Chloroform is a clear, colorless, nonflammable, volatile liquid with a pleasant sweet odor. This document establishes procedures for the safe handling and use of chloroform.

Standard Operating Procedure for Ethidium Bromide

This document establishes procedures for the safe handling and disposal of Ethidium Bromide (CAS# 1239-45-8, commonly abbreviated EtBr). Ethidium bromide is frequently used in molecular biology laboratories as a nucleic acid stain due to its ability to intercalate DNA and its fluorescent properties when exposed to ultraviolet light.

Standard Operating Procedure for Formaldehyde Solution Use in Small Animal Perfusion

Formaldehyde is a colorless, highly toxic, and flammable gas at room temperature. It is a strong smelling chemical which is commonly used in research and medical laboratories as an aqueous solution. This document establishes procedures for the safe handling and use of formaldehyde, formalin, and paraformaldehyde solutions used in perfusions.

Standard Operating Procedure for Hydrofluoric Acid

Hydrofluoric acid is extremely corrosive and highly toxic by inhalation, ingestion, and skin absorption. It differs from other acids because it readily penetrates the skin and dissociates into fluoride ions, causing destruction of deep tissue layers, including bone. Hydrofluoric acid vapors are also an inhalation hazard and can cause ocular irritation. This document establishes procedures for the safe handling and use of hydrofluoric acid (CAS# 7664‐39‐3), also known as HF.

Standard Operating Procedure for Isoflurane

Isoflurane is a halogenated anesthetic gas commonly used in University animal research facilities and individual laboratories. This document establishes procedures for the safe handling and use of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (CAS# 26675-46-7), commonly known as isoflurane or Forane®.

Standard Operating Procedure for MS-222 (Ethyl 3-Aminobenzoate Methanesulfonate, Tricaine Methanesulfonate)

MS-222 is commonly used in University animal research facilities and individual laboratories for anesthesia or euthanasia of fish, amphibians and other aquatic, cold-blooded animals. This document establishes procedures for the safe handling and use of ethyl 3-aminobenzoate methanesulfonate (CAS# 886-86-2), commonly known as MS-222 or Tricaine methanesulfonate. Pharmaceutical grade MS-222 is also available (e.g., Finquel® and Tricaine-S®).

Standard Operating Procedure for Sodium Azide

Describe proper handling and disposal procedures for Sodium Azide and Sodium Azide solutions. Sodium Azide is a colorless, odorless, crystalline solid that is readily soluble in water. It is used as a preservative of samples and stock solutions in laboratories.

Standard Operating Procedure for Tamoxifen

Tamoxifen is a white, odorless, crystalline solid with a melting point of 140-144 degrees Celsius. It is an antineoplastic agent used to treat breast cancer and is used in campus laboratories and animal facilities for cancer research studies. This document establishes procedures for the safe handling and use of Tamoxifen (CAS# 10540-29-1).

Standard Operating Procedure for Tetrodotoxin

Tetrodotoxin is an extremely potent poison (toxin) found mainly in the liver and sex organs (gonads) of some fish, such as puffer fish, globefish, and toadfish (order Tetraodontiformes) and in some amphibian, octopus, and shellfish species. Human poisonings commonly occur when the flesh and/or organs of the fish are improperly prepared and eaten.

Standard Operating Procedure for Urethane (Ethyl Carbamate, Carbamic Acid Ethyl Ester)

Urethane is an anesthetic commonly used alone or in combination with other drugs in university animal research facilities and individual laboratories. This document establishes procedures for the safe handling and use of urethane (CAS# 51-79-6).

Standard Operating Procedure for Use of DMBA in Animals

This document establishes procedures for the safe handling and use of 7,12-dimethylbenz(a)anthracene, commonly known as DMBA (CAS# 57-97-6) in university Division of Comparative Medicine (DCM; formerly the Division of Laboratory Animal Medicine (DLAM)) facilities. DMBA is a highly potent carcinogen that causes cancer and heritable genetic damage and is used to induce cancer in animal models.