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The standards and procedures described in this document provide guidance to all researchers and animal handlers for the acclimation period for received animal transfer/shipments.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the establishment and maintenance of a Satellite Animal Facility.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the environmental enrichment of research animals.

The standards and procedures described below provide guidance to all researchers and animal handlers experiencing non-compliance with the approved Institutional Animal Care and Use Committee (IACUC) protocol, animal welfare issues, and/or unanticipated adverse outcomes.

Projects involving administration of radionuclides to animals require information on specific arrangements for housing the animals during the project. Information required includes: The kind and number of animals to be used in the study (# per experiment + total # of experiments). The radionuclide to be administered per animal and how administered. The ultimate fate of the animal and suspected excretion rate of the radionuclide.

This policy provides those involved in animal care and use at the University with the resources needed to enhance animal well-being, the quality of research, and the advancement of scientific knowledge that is relevant to both humans and animal and to remain in compliance with all animal welfare regulations.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the maintenance of required standard documentation.

This chapter covers the hazards associated with laboratory animal handling, mandatory and recommended control practices, the institutional structures that UNC-Chapel Hill has in place to assure animal welfare, and requirements for using hazardous agents in laboratory animals.

This guidance is provided for the use of experimentally infected animals housed in indoor research facilities (e.g., vivaria), and is also useful in the maintenance of laboratory animals that may naturally harbor zoonotic infectious agents. In both instances, the institutional management must provide facilities, staff, and established practices that reasonably ensure appropriate levels of environmental quality, safety, security and care for laboratory animal.

The standards and procedures described in this document provide guidance to all researchers and animal handlers to ensure that sick animals are identified and adequate veterinary care is provided to all animals utilized in our research program.

The University of North Carolina at Chapel Hill is required to report an annual census of the number of animals used in research and teaching, the type of species used, and the number of animals placed in each of the four “Pain Categories (B, C, D and E).” The intent of this document is to provide general recommendations and guidance on how to assign animals to the different pain categories.

The standards and procedures described in this document provide guidance to all investigators and animal handlers on how to safely transport animals across UNC facilities and between UNC facilities and off campus sites.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the responsibility of the Principal Investigator (PI) to ensure that all institutional regulations are implemented within the PI maintained areas, for animals maintained and tested for limited periods greater than 12 hours for USDA-regulated species and 24 hour for non-USDA regulated species.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the adoption process of companion animals at UNC when they are no longer appropriate for research or teaching purposes.

This document establishes a procedure for the safe handling and use of streptozotocin, commonly known as STZ (CAS# 18883-66-4), in the university Division of Comparative Medicine (DCM) large animal facilities. STZ is a flammable solid and suspected of causing genetic defects and cancer. STZ is commonly used to induce diabetes in animals. It is a non-volatile solid and inhalation of dust should be prevented.