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This document serves to describe the University’s Standards for creating and maintaining aseptic conditions during survival procedures in USDA covered species, while also providing a standard for the pre and post-operative management.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the environmental enrichment of research animals.

The standards and procedures described below provide guidance regarding expectations for Institutional Animal Care and Use Committee (IACUC) member participation at the University of North Carolina at Chapel Hill ("UNC-Chapel Hill" or "University").

The standards and procedures described in this document provide guidance to all researchers and animal handlers utilizing adjuvants for antibody production with a special emphasis on Freund ’s adjuvant. This standard is adopted from National Institutes of Health (NIH) Office of Animal Care and Use’s (OACU) Guide.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the establishment and maintenance of a Satellite Animal Facility.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for ensuring adequate aseptic technique for all non-USDA regulated rodent (i.e., mice and rats) survival surgeries.

The standards and procedures described in this document provide guidance to all researchers and animal handlers regarding identification of pain in animals and appropriate analgesia for post-operative and Pain Category D procedures to prevent pain.

The purpose of this Standard is to ensure sufficient space for rats with litters that will allow pups to develop to weaning age without detrimental effects, and to house adult rats in space that is sufficient for their needs.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the exercise and socialization of canines at UNC-Chapel Hill according to current Animal Welfare Act Regulations (AWA) and "Guide" recommendations.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for safely disposing of rodent carcasses across UNC research animal facilities.

The standards and procedures described in this document provide guidance to all investigators and animal handlers on how to safely transport animals across UNC facilities and between UNC facilities and off campus sites.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the responsibility of the Principal Investigator (PI) to ensure that all institutional regulations are implemented within the PI maintained areas, for animals maintained and tested for limited periods greater than 12 hours for USDA-regulated species and 24 hour for non-USDA regulated species.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the adoption process of companion animals at UNC when they are no longer appropriate for research or teaching purposes.

The standards and procedures in this document provide guidance to all researchers and animal handlers for performing blood withdrawals and tail biopsies in mice and rats.

This chapter covers the hazards associated with laboratory animal handling, mandatory and recommended control practices, the institutional structures that UNC-Chapel Hill has in place to assure animal welfare, and requirements for using hazardous agents in laboratory animals.