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This document establishes a procedure for the safe handling and use of streptozotocin, commonly known as STZ (CAS# 18883-66-4), in the university Division of Comparative Medicine (DCM) large animal facilities. STZ is a flammable solid and suspected of causing genetic defects and cancer. STZ is commonly used to induce diabetes in animals. It is a non-volatile solid and inhalation of dust should be prevented.