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The standards and procedures described in this document provide guidance to all researchers and animal handlers utilizing adjuvants for antibody production with a special emphasis on Freund ’s adjuvant. This standard is adopted from National Institutes of Health (NIH) Office of Animal Care and Use’s (OACU) Guide.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for requirements for humane endpoints for mice and rats in cancer studies.

This document serves to describe the University’s Standards for creating and maintaining aseptic conditions during survival procedures in USDA covered species, while also providing a standard for the pre and post-operative management.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the establishment and maintenance of a Satellite Animal Facility.

The standards and procedures described in this document provide guidance to all researchers and animal handlers regarding identification of pain in animals and appropriate analgesia for post-operative and Pain Category D procedures to prevent pain.

This document is intended to ensure sufficient space for mice with litters that will allow pups to develop to weaning without detrimental effects, and to house adult mice in space that is sufficient for their needs. This Standard is a blend of the requirements in the 8th edition of the Guide for the Care and Use of Laboratory Animals and the long-standing, performance-based UNC policy.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the exercise and socialization of canines at UNC-Chapel Hill according to current Animal Welfare Act Regulations (AWA) and "Guide" recommendations.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for safely disposing of rodent carcasses across UNC research animal facilities.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the responsibility of the Principal Investigator (PI) to ensure that all institutional regulations are implemented within the PI maintained areas, for animals maintained and tested for limited periods greater than 12 hours for USDA-regulated species and 24 hour for non-USDA regulated species.

The standards and procedures in this document provide guidance to all researchers and animal handlers for performing blood withdrawals and tail biopsies in mice and rats.

The standards and procedures described in this document provide guidance in documentation to all researchers and animal handlers performing duties that would normally be performed by Division of Comparative Medicine (DCM) Husbandry staff (i.e. feed, water, cage change).

The standards and procedures described in this document provide guidance to all researchers and animal handlers for the environmental enrichment of research animals.

This chapter covers the hazards associated with laboratory animal handling, mandatory and recommended control practices, the institutional structures that UNC-Chapel Hill has in place to assure animal welfare, and requirements for using hazardous agents in laboratory animals.

This document establishes a procedure for the safe handling and use of streptozotocin, commonly known as STZ (CAS# 18883-66-4), in the university Division of Comparative Medicine (DCM) large animal facilities. STZ is a flammable solid and suspected of causing genetic defects and cancer. STZ is commonly used to induce diabetes in animals. It is a non-volatile solid and inhalation of dust should be prevented.

The standards and procedures described in this document provide guidance to all researchers and animal handlers for ensuring adequate aseptic technique for all non-USDA regulated rodent (i.e., mice and rats) survival surgeries.